Cryo-Electron Microscopy (Cryo-EM) for Structural Imaging
Providing advanced Cryo-EM systems for visualizing biomolecules and nanostructures in near-native states at atomic resolution.
Transformative Imaging Cryo-EM Systems
Cryo-Electron Microscopy (Cryo-EM) is a transformative imaging technique that allows researchers to visualize biological samples and nanomaterials at near-atomic resolution—without staining or chemical fixation. By flash-freezing samples and imaging them under cryogenic conditions, Cryo-EM captures molecular structures in their most native and hydrated states. This approach is especially powerful for studying viruses, proteins, and cellular complexes that are difficult to crystallize.
Used across North America in leading research centers and pharmaceutical labs, Cryo-EM is driving breakthroughs in structural biology, drug discovery, and nanotechnology. MICROSCOPY AND IMAGING supports this demand by offering tailored Cryo-EM systems for high-resolution imaging and analysis. As a B2B provider focused on innovation and product reliability, we empower organizations with advanced microscopy platforms that integrate seamlessly into research pipelines. Backed by rigorous quality control and expert technical guidance, MICROSCOPY AND IMAGING helps unlock the full potential of Cryo-EM for science and industry.
Core Components of Cryo-EM Systems
In addition to offering products and systems developed by our team and trusted partners for Cryo-Electron Microscopy (Cryo-EM), we are proud to carry top-tier technologies from Global Advanced Operations Tek Inc. (GAO Tek Inc.) and Global Advanced Operations RFID Inc. (GAO RFID Inc.). These reliable, high-quality products and systems enhance our ability to deliver comprehensive technologies, integrations, and services you can trust. Where relevant, we have provided direct links to select products and systems from GAO Tek Inc. and GAO RFID Inc.
Hardware
- Cryogenic sample holders and cooling stages
Temperature & Process Calibrators (Environmental Test Instruments)– ensure precise thermal control and cryo-stability for biological samples. - High-voltage electron sources with field emission guns (FEGs)
Function Generators (Electrical Testers)– used for precise electron emission modulation and system calibration. - Direct electron detectors with fast readout capabilities
Display Screens (Electronics)– integrated for high-speed visualization and signal output from detectors. - Automated specimen loading and robotic handling systems
Industrial Tablet PCs (Electronics)– provide real-time control interfaces for robotic automation in cryogenic environments. - Vacuum chambers with anti-contamination shielding
Hydrogen Gas Detectors (Commercial Gas Detectors)– monitor vacuum integrity and detect trace leaks from cryogenic gases.
Software
- Real-time control of beam alignment and focus
- Automated particle detection and classification
- 2D/3D image reconstruction and single-particle analysis
- Tomography and sub-tomogram averaging modules
- Workflow tracking, audit trails, and data export tools
Cloud Services
- Cloud-based processing of massive Cryo-EM datasets
- Secure image backup and remote access
- Scalable storage for time-lapse and tomography data
- Multi-user collaboration and data annotation environments
Key Features and Functionalities
- Imaging at near-atomic resolution (sub-3 Å in ideal conditions)
- Sample preservation in vitreous ice without staining
- Compatible with single-particle analysis, tomography, and electron crystallography
- Automated data acquisition with high-throughput screening
- Integrated temperature control and anti-drift systems
- Advanced optics and camera systems for high signal-to-noise imaging
Integrations
MICROSCOPY AND IMAGING’s Cryo-EM systems integrate with:
- Automated sample preparation stations (e.g., vitrification robots)
- AI-assisted structure modeling and refinement platforms
- LIMS and secure data management tools
- Cryo-focused ion beam (Cryo-FIB) milling systems
- Cloud-based reconstruction tools and supercomputing clusters
Compatibility
- Compatible with third-party cryo-prep tools (e.g., Vitrobot, Leica EM GP2)
- Supports major reconstruction software such as RELION, CryoSPARC, and cisTEM
- Interoperable with high-performance GPU and CPU environments
- Works within Windows or Linux server architecture
- Export-ready for downstream analysis or publication graphics
Benefits
- Enables visualization of proteins, viruses, and cell structures in native conditions
- Eliminates the need for crystallization or staining
- Suitable for dynamic molecular studies and structural comparisons
- Supports pharmaceutical R&D with precise target visualization
- Streamlines workflows from preparation to publication with automation
- Backed by MICROSCOPY AND IMAGING’s robust quality assurance and expert customer support
Applications
- Structural biology of macromolecules and protein complexes
- Drug discovery and target validation
- Pathogen visualization and vaccine design
- Nanomaterials imaging in hydrated states
- Cryo-electron tomography of organelles and cells
- High-resolution virology and molecular genetics research
Industries
- Biopharmaceutical Research & Development
- Academic Research Institutions & Core Facilities
- Molecular Biology & Genomics
- Vaccine & Therapeutic Design
- Nanotechnology & Material Sciences
- Government & Public Health Research
Relevant Industry Standards
ISO 13485
FDA 21 CFR Part 11
GLP (Good Laboratory Practice)
CLIA Laboratory Standards
Health Canada Medical Device Regulations
Case Studies
University Biomedical Lab, Massachusetts
A top-tier research university partnered with MICROSCOPY AND IMAGING to build a dedicated Cryo-EM facility for studying protein folding disorders. Using our high-throughput system, the team captured near-atomic structures of amyloid fibrils, contributing to a breakthrough study on neurodegenerative diseases.
Biotech Startup, San Diego
A biotechnology firm focused on RNA therapeutics adopted MICROSCOPY AND IMAGING’s Cryo-EM solution to visualize RNA-ligand interactions. The automated workflow enabled the team to screen compound libraries faster, accelerating lead optimization and pre-clinical development.
Canadian Pathology Lab, Ontario
A national research institute integrated our Cryo-EM platform to enhance their pipeline for protein complex analysis. By combining Cryo-EM with cloud-based reconstruction tools, the lab increased throughput and secured funding through international collaborative grants
Interested in implementing Cryo-Electron Microscopy in your lab or facility?
Contact us for tailored guidance, technical specifications, and integration support. Our experts are ready to help you design a scalable Cryo-EM solution that fits your workflow, research, or commercial goals.